COMPARISON OF THE EFFECTS OF CIMETIDINE AND TRAMADOL ON THE DISPOSITION OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS
ABSTRACT
The influence of cimetidine (400mg) and Tramadol (100mg) on the disposition of oral single dose (1g) Paracetamol was studied and compared in 8 healthy human volunteers under two protocols; concomitant and delayed paracetamol administration.
Subjects received one treatment at each of five sessions 2wk apart. Ingestion of Paracetamol (1g) alone was used as control and compared with paracetamol concentration on concomitant (with tramadol (100mg) and then cimetidine (1g)) and delayed administration (1h 45mins after tramadol and 1h after cimetidine). Saliva paracetamol concentrations were determined with UV-Spectrophotometer. Pharmacokinetic parameters (kab, t1/2ab, kel, t1/2el and lag time), were determined by plotting paracetamol concentrations against time on a logarithmic scale while other parameters were calculated.